DC FieldValueLanguage
dc.contributorSchool of Optometryen_US
dc.creatorWang Q.en_US
dc.creatorBanerjee S.en_US
dc.creatorSo C.en_US
dc.creatorQiu C.en_US
dc.creatorLam H.-I.C.en_US
dc.creatorTse, Den_US
dc.creatorVölgyi, Ben_US
dc.creatorPan, Fen_US
dc.date.accessioned2021-04-09T08:50:53Z-
dc.date.available2021-04-09T08:50:53Z-
dc.identifier.issn0892-6638en_US
dc.identifier.urihttp://hdl.handle.net/10397/89532-
dc.language.isoenen_US
dc.publisherFederation of American Societies for Experimental Biologyen_US
dc.subjectGanglion cellen_US
dc.subjectInhibitionen_US
dc.subjectNeurodegenerative diseaseen_US
dc.subjectRetinaen_US
dc.subjectVisionen_US
dc.titleUnmasking inhibition prolongs neuronal function in retinal degeneration mouse modelen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage15282en_US
dc.identifier.epage15299en_US
dc.identifier.volume34en_US
dc.identifier.issue11en_US
dc.identifier.doi10.1096/fj.202001315RRen_US
dcterms.abstractAll neurodegenerative diseases involve a relatively long period of timeframe from the onset of the disease to complete loss of functions. Extending this timeframe, even at a reduced level of function, would improve the quality of life of patients with these devastating diseases. The retina, as the part of the central nervous system and a frequent site of many distressing neurodegenerative disease, provides an ideal model to investigate the feasibility of extending the functional timeframe through pharmacologic intervention. Retinitis Pigmentosa (RP) is a group of blinding diseases. Although the rate of progression and degree of visual loss varies, there is usually a prolonged time before patients totally lose their photoreceptors and vision. It is believed that inhibitory mechanisms are still intact and may become relatively strong after the gradual loss of photoreceptors in RP patients. Therefore, it is possible that light-evoked responses of retinal ganglion cells and visual information processes in retinal circuits could be “unmasked” by blocking these inhibitory mechanisms restoring some level of visual function. Our results indicate that if the inhibition in the inner retina was unmasked in the retina of the rd10 mouse (the well-characterized RP mimicking, clinically relevant mouse model), the light-evoked responses of many retinal ganglion cells can be induced and restore their normal light sensitivity. GABA A receptor plays a major role in this masking inhibition. ERG b-wave and behavioral tests of spatial vision partly recovered after the application of PTX. Hence, removing retinal inhibition unmasks signalling mediated by surviving cones, thereby restoring some degree of visual function. These results may offer a novel strategy to restore the visual function with the surviving cones in RP patients and other gradual and progressive neurodegenerative diseases.en_US
dcterms.accessRightsembargoed accessen_US
dcterms.bibliographicCitationFASEB journal, Nov. 2020, v. 34, no. 11, p. 15282-15299en_US
dcterms.isPartOfFASEB journalen_US
dcterms.issued2020-11-
dc.identifier.scopus2-s2.0-85091609976-
dc.identifier.pmid32985731-
dc.identifier.eissn1530-6860en_US
dc.description.validate202104 bcrcen_US
dc.description.oaNot applicableen_US
dc.identifier.FolderNumbera0644-n02-
dc.identifier.SubFormID704-
dc.description.pubStatusPublisheden_US
dc.date.embargo2021.11.30en_US
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