| DC Field | Value | Language |
|---|---|---|
| dc.contributor | Department of Applied Biology and Chemical Technology | - |
| dc.creator | Dai, L | - |
| dc.creator | Zhang, J | - |
| dc.creator | Wong, CT | - |
| dc.creator | Chan, WTK | - |
| dc.creator | Ling, X | - |
| dc.creator | Anderson, CJ | - |
| dc.creator | Law, GL | - |
| dc.date.accessioned | 2021-05-13T08:31:32Z | - |
| dc.date.available | 2021-05-13T08:31:32Z | - |
| dc.identifier.issn | 0020-1669 | - |
| dc.identifier.uri | http://hdl.handle.net/10397/89822 | - |
| dc.language.iso | en | en_US |
| dc.publisher | American Chemical Society | en_US |
| dc.title | Design of functional chiral cyclen-based radiometal chelators for theranostics | en_US |
| dc.type | Journal/Magazine Article | en_US |
| dc.identifier.doi | 10.1021/acs.inorgchem.0c03734 | - |
| dcterms.abstract | A series of water-soluble chiral cyclen-based chelators with chemical handles for selective targeting have been synthesized (cyclen = 1,4,7,10-Tetraazacyclododecane). Optical studies, relaxivity measurements, and competitive titrations were performed to show the versatility of these chiral chelators. The complexations of L3, L4, and L5 with Lu3+, Y3+, Sc3+, and Cu2+ were successfully demonstrated in around 90% to 100% yields. Efficient and rapid radiolabeling of L5 with 177Lu was achieved under mild conditions with 96% yield. The chelators exhibit near quantitative labeling efficiencies with a wide range of radiometal ions, which are promising for the development of targeting specific radiopharmaceutical and molecular magnetic resonance imaging contrast agents. | - |
| dcterms.accessRights | embargoed access | - |
| dcterms.bibliographicCitation | Inorganic chemistry, 2021, https://doi.org/10.1021/acs.inorgchem.0c03734 | - |
| dcterms.isPartOf | Inorganic chemistry | - |
| dcterms.issued | 2021 | - |
| dc.identifier.scopus | 2-s2.0-85103460403 | - |
| dc.description.validate | 202105 bchy | - |
| dc.description.oa | Not applicable | - |
| dc.identifier.FolderNumber | a0741-n01 | - |
| dc.identifier.SubFormID | 1422 | - |
| dc.description.fundingSource | RGC | - |
| dc.description.fundingText | PolyU153009/19P, PolyU153013/17P | - |
| dc.description.pubStatus | Early release | - |
| dc.date.embargo | 0000-00-00 (to be updated) | en_US |
| Appears in Collections: | Journal/Magazine Article | |
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