DC FieldValueLanguage
dc.contributorInstitute of Textiles and Clothing-
dc.contributorDepartment of Biomedical Engineering-
dc.contributorDepartment of Health Technology and Informatics-
dc.creatorMa, L-
dc.creatorZhang, Z-
dc.creatorLi, J-
dc.creatorYang, X-
dc.creatorFei, B-
dc.creatorLeung, PHM-
dc.creatorTao, X-
dc.date.accessioned2021-05-18T08:21:04Z-
dc.date.available2021-05-18T08:21:04Z-
dc.identifier.urihttp://hdl.handle.net/10397/90120-
dc.language.isoenen_US
dc.publisherWiley-VCHen_US
dc.subjectAntibacterial mechanismen_US
dc.subjectAntimicrobial agenten_US
dc.subjectExtractionen_US
dc.subjectOligomeren_US
dc.subjectPoly (3-hydroxybutyric acid)en_US
dc.subjectSynthesisen_US
dc.titleA new antimicrobial agent : poly (3-hydroxybutyric acid) oligomeren_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.volume19-
dc.identifier.issue5-
dc.identifier.doi10.1002/mabi.201800432-
dcterms.abstractIn this work, it is first reported that the poly (3-hydroxybutyric acid) (PHB) oligomer with a few degrees of polymerization possesses effective antibacterial and antifungal properties. Two preparation methods for the PHB oligomer are described, namely, one-step ring-opening polymerization of β-butyrolactone and extraction from the fermented PHB polymer. An appropriate amount of the synthesized PHB oligomer shows no physiological toxicity to the skin and major organs of mice. Topological application of the synthesized PHB oligomer imparts antimicrobial ability to non-antibacterial fabrics with washing resistance. The synthesized PHB oligomer offers effective sterilization and promotes wound healing in infected nude mice. Most importantly, the PHB oligomer is also reactive to drug-resistant bacteria. These results suggest that the PHB oligomer is not only a great candidate for antimicrobial modification but also a promising one for biomedical applications. Finally, the antimicrobial mechanisms of the PHB oligomer are revealed, and these include disruption of biofilm and the bacterial wall/membrane, leakage of the intracellular content, inhibition of protein activity, and change in the transmembrane potential.-
dcterms.bibliographicCitationMacromolecular bioscience, May 2019, v. 19, no. 5, 1800432-
dcterms.isPartOfMacromolecular bioscience-
dcterms.issued2019-05-
dc.identifier.scopus2-s2.0-85063957969-
dc.identifier.pmid30951260-
dc.identifier.eissn1616-5187-
dc.identifier.artn1800432-
dc.description.validate202105 bchy-
dc.identifier.FolderNumbera0671-n06-
dc.description.fundingSourceOthers-
dc.description.fundingTextOthers: P0012725-
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