| DC Field | Value | Language |
|---|---|---|
| dc.contributor | Department of Applied Biology and Chemical Technology | - |
| dc.contributor | Institute of Textiles and Clothing | - |
| dc.creator | Lam, KH | - |
| dc.creator | Gambari, R | - |
| dc.creator | Yuen, MCW | - |
| dc.creator | Kan, CW | - |
| dc.creator | Chan, P | - |
| dc.creator | Xu, JL | - |
| dc.creator | Tang, WJ | - |
| dc.creator | Chui, CH | - |
| dc.creator | Cheng, GYM | - |
| dc.creator | Wong, RSM | - |
| dc.creator | Lau, FY | - |
| dc.creator | Tong, SCW | - |
| dc.creator | Chan, AKW | - |
| dc.creator | Lai, PBS | - |
| dc.creator | Kok, SHL | - |
| dc.creator | Cheng, CH | - |
| dc.creator | Chan, ASC | - |
| dc.creator | Tang, JCO | - |
| dc.date.accessioned | 2016-12-19T08:52:09Z | - |
| dc.date.available | 2016-12-19T08:52:09Z | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.uri | http://hdl.handle.net/10397/60496 | - |
| dc.language.iso | en | en_US |
| dc.publisher | Pergamon Press | en_US |
| dc.title | The preparation of 2,6-disubstituted pyridinyl phosphine oxides as novel anti-cancer agents | en_US |
| dc.type | Journal/Magazine Article | en_US |
| dc.identifier.spage | 2266 | - |
| dc.identifier.epage | 2269 | - |
| dc.identifier.volume | 19 | - |
| dc.identifier.issue | 8 | - |
| dc.identifier.doi | 10.1016/j.bmcl.2009.02.091 | - |
| dcterms.abstract | A series of 2,6-dimethoxylpyridinyl phosphine oxides have been synthesized and examined for their antitumor activity. 2,6-Dimethoxy-3-phenyl-4-diphenylphosphinoylpyridine 2 has been employed as the lead compound for this study. We found out that the presence of phosphine oxide on the 2,6-dimethoxylpyridine ring is important for the antitumor activity; the presence of bromine on this core leads to a further enhancement of its antitumor activity. This is the first reported work on the antitumor activity of the 2,6-dimethoxy-3,5-dibromopyridinyl phosphine oxide 5b towards MDAMB-231 breast cancer and SKHep-1 hepatoma cell lines. | - |
| dcterms.bibliographicCitation | Bioorganic & medicinal chemistry letters, 2009, v. 19, no. 8, p. 2266-2269 | - |
| dcterms.isPartOf | Bioorganic & medicinal chemistry letters | - |
| dcterms.issued | 2009 | - |
| dc.identifier.eissn | 1464-3405 | - |
| dc.identifier.rosgroupid | r42842 | - |
| dc.description.ros | 2008-2009 > Academic research: refereed > Publication in refereed journal | - |
| Appears in Collections: | Journal/Magazine Article | |
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