| Title: | The preparation of 2,6-disubstituted pyridinyl phosphine oxides as novel anti-cancer agents | Authors: | Lam, KH Gambari, R Yuen, MCW Kan, CW Chan, P Xu, JL Tang, WJ Chui, CH Cheng, GYM Wong, RSM Lau, FY Tong, SCW Chan, AKW Lai, PBS Kok, SHL Cheng, CH Chan, ASC Tang, JCO |
Issue Date: | 2009 | Source: | Bioorganic & medicinal chemistry letters, 2009, v. 19, no. 8, p. 2266-2269 | Abstract: | A series of 2,6-dimethoxylpyridinyl phosphine oxides have been synthesized and examined for their antitumor activity. 2,6-Dimethoxy-3-phenyl-4-diphenylphosphinoylpyridine 2 has been employed as the lead compound for this study. We found out that the presence of phosphine oxide on the 2,6-dimethoxylpyridine ring is important for the antitumor activity; the presence of bromine on this core leads to a further enhancement of its antitumor activity. This is the first reported work on the antitumor activity of the 2,6-dimethoxy-3,5-dibromopyridinyl phosphine oxide 5b towards MDAMB-231 breast cancer and SKHep-1 hepatoma cell lines. | Publisher: | Pergamon Press | Journal: | Bioorganic & medicinal chemistry letters | ISSN: | 0960-894X | EISSN: | 1464-3405 | DOI: | 10.1016/j.bmcl.2009.02.091 |
| Appears in Collections: | Journal/Magazine Article |
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