DC FieldValueLanguage
dc.contributorDepartment of Biomedical Engineering-
dc.creatorXu, J-
dc.creatorCheng, X-
dc.creatorChen, F-
dc.creatorLi, W-
dc.creatorXiao, X-
dc.creatorLai, P-
dc.creatorXu, G-
dc.creatorXu, L-
dc.creatorPan, Y-
dc.date.accessioned2021-05-13T08:31:30Z-
dc.date.available2021-05-13T08:31:30Z-
dc.identifier.issn2238-7854-
dc.identifier.urihttp://hdl.handle.net/10397/89816-
dc.language.isoenen_US
dc.publisherElsevier Editora Ltdaen_US
dc.subjectImagingen_US
dc.subjectMultifunctional nanobonesen_US
dc.subjectPhotothermal therapyen_US
dc.titleFabrication of multifunctional polydopamine-coated gold nanobones for PA/CT imaging and enhanced synergistic chemo-photothermal therapyen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage97-
dc.identifier.epage105-
dc.identifier.volume63-
dc.identifier.doi10.1016/j.jmst.2020.04.060-
dcterms.abstractMultimodal imaging-guided chemo-photothermal therapy is an excellent cancer treatment, which can not only efficiently against tumor, but also can offer precise treatment window and real-time monitoring of the treatment efficiency. In our work, polydopamine (PDA)-coated gold nanobones (AuNBs@PDA nanocomplexes) were designed for this approach. The AuNBs@PDA nanocomplexes have strong absorbance in the near infrared (NIR) region and higher photothermal conversion efficiency (75.48 %) than gold nanobones alone, which was facilitated for photoacoustic imaging and photothermal therapy. Besides, the loading efficiency of doxorubicin (DOX) by AuNBs@PDA nanocomplexes could be up to about 70 % and DOX release from AuNBs@PDA/DOX nanocomplexes sensitively response to the lower pH environment and NIR laser irradiation, which makes them become the excellent nano-carrier for the delivery of chemotherapy drug. In vitro and in vivo studies showed significant cytotoxicity and antitumor efficacy by the AuNBs@PDA/DOX nanoplatform with negligible side effects. Meanwhile, the nanoplatform was also successfully employed for computed tomography (CT) imaging, attributing to the high atomic number and high X-ray attenuation coefficient of gold. Therefore, we believed that the proposed PDA-coated gold nanobones would be a novel multifunctional theranostic nanoagent to realize the PA/CT imaging-guided chemo-photothermal therapy of cancer.-
dcterms.accessRightsembargoed accessen_US
dcterms.bibliographicCitationJournal of materials science and technology (Brazil), 10 Feb. 2021, v. 63, p. 97-105-
dcterms.isPartOfJournal of materials science and technology (Brazil)-
dcterms.issued2021-02-
dc.identifier.scopus2-s2.0-85090830318-
dc.identifier.eissn2214-0697-
dc.description.validate202105 bchy-
dc.description.oaNot applicableen_US
dc.identifier.FolderNumbera0840-n24-
dc.identifier.SubFormID1813-
dc.description.fundingSourceOthersen_US
dc.description.fundingTextP0020279, P0030396en_US
dc.description.pubStatusPublisheden_US
dc.date.embargo2023.02.28en_US
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