| Title: | Fabrication of multifunctional polydopamine-coated gold nanobones for PA/CT imaging and enhanced synergistic chemo-photothermal therapy | Authors: | Xu, J Cheng, X Chen, F Li, W Xiao, X Lai, P Xu, G Xu, L Pan, Y |
Issue Date: | Feb-2021 | Source: | Journal of materials science and technology (Brazil), 10 Feb. 2021, v. 63, p. 97-105 | Abstract: | Multimodal imaging-guided chemo-photothermal therapy is an excellent cancer treatment, which can not only efficiently against tumor, but also can offer precise treatment window and real-time monitoring of the treatment efficiency. In our work, polydopamine (PDA)-coated gold nanobones (AuNBs@PDA nanocomplexes) were designed for this approach. The AuNBs@PDA nanocomplexes have strong absorbance in the near infrared (NIR) region and higher photothermal conversion efficiency (75.48 %) than gold nanobones alone, which was facilitated for photoacoustic imaging and photothermal therapy. Besides, the loading efficiency of doxorubicin (DOX) by AuNBs@PDA nanocomplexes could be up to about 70 % and DOX release from AuNBs@PDA/DOX nanocomplexes sensitively response to the lower pH environment and NIR laser irradiation, which makes them become the excellent nano-carrier for the delivery of chemotherapy drug. In vitro and in vivo studies showed significant cytotoxicity and antitumor efficacy by the AuNBs@PDA/DOX nanoplatform with negligible side effects. Meanwhile, the nanoplatform was also successfully employed for computed tomography (CT) imaging, attributing to the high atomic number and high X-ray attenuation coefficient of gold. Therefore, we believed that the proposed PDA-coated gold nanobones would be a novel multifunctional theranostic nanoagent to realize the PA/CT imaging-guided chemo-photothermal therapy of cancer. | Keywords: | Imaging Multifunctional nanobones Photothermal therapy |
Publisher: | Elsevier Editora Ltda | Journal: | Journal of materials science and technology (Brazil) | ISSN: | 2238-7854 | EISSN: | 2214-0697 | DOI: | 10.1016/j.jmst.2020.04.060 |
| Appears in Collections: | Journal/Magazine Article |
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