| Title: | Design of functional chiral cyclen-based radiometal chelators for theranostics | Authors: | Dai, L Zhang, J Wong, CT Chan, WTK Ling, X Anderson, CJ Law, GL |
Issue Date: | 2021 | Source: | Inorganic chemistry, 2021, https://doi.org/10.1021/acs.inorgchem.0c03734 | Abstract: | A series of water-soluble chiral cyclen-based chelators with chemical handles for selective targeting have been synthesized (cyclen = 1,4,7,10-Tetraazacyclododecane). Optical studies, relaxivity measurements, and competitive titrations were performed to show the versatility of these chiral chelators. The complexations of L3, L4, and L5 with Lu3+, Y3+, Sc3+, and Cu2+ were successfully demonstrated in around 90% to 100% yields. Efficient and rapid radiolabeling of L5 with 177Lu was achieved under mild conditions with 96% yield. The chelators exhibit near quantitative labeling efficiencies with a wide range of radiometal ions, which are promising for the development of targeting specific radiopharmaceutical and molecular magnetic resonance imaging contrast agents. | Publisher: | American Chemical Society | Journal: | Inorganic chemistry | ISSN: | 0020-1669 | DOI: | 10.1021/acs.inorgchem.0c03734 |
| Appears in Collections: | Journal/Magazine Article |
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