Title: Ligand control of palladium-catalyzed site-selective α- and γ-Arylation of α,β-Unsaturated Ketones with (Hetero)aryl Halides
Authors: Yuen, OY 
So, CM 
Issue Date: 21-Dec-2020
Source: Angewandte chemie international edition, 21 Dec. 2020, v. 59, no. 52, p. 23438-23444
Abstract: This study describes the first palladium-catalyzed, site-selective α- and γ-arylation of α,β-unsaturated ketones with (hetero)aryl halides. A wide range of hetero(aryl)halides coupled with α,β-unsaturated ketones, and transformation into the arylated products proceeded with excellent to good yields. The site selectivity of the reaction is switchable by simply changing the phosphine ligand to access either α-arylated or γ-arylated products in good to excellent yields by using a low catalyst loading, and the method demonstrates good functional-group compatibility.
Keywords: Arylation
Cross-coupling
Ketones
Ligand design
Synthetic methods
Publisher: Wiley-VCH
Journal: Angewandte chemie international edition 
ISSN: 1433-7851
EISSN: 1521-3773
DOI: 10.1002/anie.202010682
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.